Cosmelan vs. Dermamelan: Which Pigmentation Treatment Do I Recommend?

By Dr. PK, Kaya Cosmedica

If you’re struggling with melasma, sun spots, or post-inflammatory pigmentation, you’ve probably come across Cosmelan and Dermamelan in your research. These are two of the most well-known medical depigmentation treatments available today, and they work by reducing melanin production at the source to lighten pigmentation and even out skin tone.

But which one is better? And why do I choose to offer Dermamelan over Cosmelan at Kaya Cosmedica?

Let’s break it down.

What’s the Difference Between Cosmelan and Dermamelan?

Both Cosmelan and Dermamelan are designed to treat hyperpigmentation, melasma, and uneven skin tone by targeting excess melanin production. They work through a combination of an in-clinic depigmentation mask and a structured home-care routine that helps prevent new pigmentation from forming.

But here’s where they differ:

• Cosmelan is great for mild to moderate pigmentation like sun spots, age spots, and general uneven skin tone.
• Dermamelan is 20-30% stronger and more effective for moderate to severe pigmentation, including stubborn melasma and post-inflammatory hyperpigmentation (PIH).

Because pigmentation can be deep-rooted and difficult to treat, I prefer Dermamelan for my patients who are serious about long-term results.

So, Which Is Better: Cosmelan or Dermamelan?

The answer depends on your skin type and the severity of pigmentation.

• If you have mild pigmentation, Cosmelan might be enough.
• If you have deep or recurring pigmentation, Dermamelan is a better choice.

At Kaya Cosmedica, I’ve chosen Dermamelan because it delivers stronger, longer-lasting results—especially for patients dealing with melasma, post-inflammatory hyperpigmentation, or pigmentation that keeps coming back despite trying multiple treatments.

Does Dermamelan Really Work?

Absolutely. Dermamelan is one of the most effective depigmentation treatments available today. Unlike standard chemical peels, which only work on the skin’s surface, Dermamelan penetrates deeper and inhibits melanin production at the source.

Here’s what you can expect:

✔ Visible improvement within 10-14 days
✔ More even skin tone and reduction in dark patches
✔ Ongoing improvement over the next few months

The key to success? Consistent home care and sun protection. If you’re not diligent about these, pigmentation can return—even with the best treatments.

How Long Do the Results Last?

This depends on how well you take care of your skin post-treatment. I always remind my patients that pigmentation is a long-term condition that needs ongoing management.

Here’s what helps results last longer:

✔ Following a dedicated home-care routine for at least six months
✔ Daily sunscreen use (and reapplication throughout the day)
✔ Avoiding excessive sun exposure and other pigmentation triggers

Some of my patients only need one Dermamelan treatment, while others come back for maintenance treatments every few years. Every skin type is different, so a personalised approach is always best.

What’s the Best Chemical Peel for Melasma?

Melasma is one of the most stubborn types of pigmentation, and regular chemical peels just don’t cut it. Standard peels only exfoliate the top layers of the skin, but melasma often sits deeper in the dermis.

This is why Dermamelan is one of the best treatments for melasma—it doesn’t just fade dark spots; it regulates melanin production to prevent them from coming back.

If you’ve struggled with melasma and haven’t seen results with other treatments, I highly recommend booking a consultation to see if Dermamelan is right for you.

What to Expect from Dermamelan Treatment

Step 1: The In-Clinic Mask

• We start with a consultation to assess your skin and determine if Dermamelan is suitable for you.
• Your skin is cleansed and prepped, then the Dermamelan mask is applied.
• The mask stays on for 8-12 hours, depending on your skin type and pigmentation severity.
• You’ll wash it off at home, and the peeling process will begin in the following days.

Step 2: Home Care & Recovery

• Your skin will peel, feel tight, and may be a little sensitive for the first week.
• You’ll follow a specific skincare routine to support the healing process.
• We schedule TWO follow-up Healite LED light treatments to boost recovery.

Post-Treatment Care & Results

✔ Peeling starts within a few days – your skin may feel tight, dry, and sensitive.
✔ Results start to show within 10-14 days, with continued improvement over several months.
✔ Strict home care and SPF use are essential to maintaining long-term results.

Are There Any Risks?

Dermamelan is a safe, clinically tested treatment, but it’s not suitable for everyone. You shouldn’t have this treatment if you: are pregnant or breastfeeding, have been on Roaccutane within the last six months, have active infections, cold sores, or open wounds or have a history of keloid scarring.

If you’re unsure whether Dermamelan is right, I recommend booking a consultation first.

Thinking About Cosmelan?
You Should Consider Dermamelan Instead

Book a Consultation at Kaya Cosmedica

If you’ve been struggling with melasma, sun damage, or persistent pigmentation, let’s find the right solution for your skin. Book a consultation at Kaya Cosmedica today to see if Dermamelan is the best option for you.

📍 Kaya Cosmedica, Melbourne
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At Kaya Cosmedica, we embrace diversity, treating all skin types. Our lovely patient came to us with pigmentation concerns, and we achieved a stunning result of glowing, evenly toned skin using Dermamelan and Synergie Cosmeceuticals. Every patient journey is unique, and results may vary.